Antagonism by Tetrabenazine of the Depressive Effects of Morphine on the Central Nervous System.

pathways in the central nervous system in rabbits and cats, like those of morphine (2). The questions arise whether the antagonistic effect by tetrabenazine of the central effects of morphine can be recognized in other species besides mice, whether all of the depressive actions of morphine on the afferent pathways of the central nervous system are suppressed by the tetrabenazine pretreatment, and whether tetrabenazine may owe its antagonistic action against morphine to its ability to deplete the catecholamines and serotonin levels in the brain. The purpose of this study was to investigate these questions using the electro